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. 2022 Apr 12;12:820510. doi: 10.3389/fonc.2022.820510

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Copyright © 2022 Diefenbach, Lee, Stewart, Menzies, Carlino, Saw, Stretch, Long, Scolyer and Rizos

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sensitivity of the custom melanoma ctDNA panel based on BRAF, NRAS or TERT promoter mutations identified across the melanoma cohort. Each circle corresponds to the 95 minimal detectable allele fraction (95MDAF) values and unique molecule depth (unique fragments covering the specified region) for a single sample. (A) BRAF V600 mutations. Data derived from samples 1, 3, 4, 9, 10, 13, 16, 19. (B) NRAS G60/Q61 mutations. Data derived from samples 2, 4, 5, 6, 9, 11, 14. (C) TERT 228-250 promoter mutations. Data derived from samples 2, 4, 5, 6, 9, 13, 14, 16, 19, 20.