TABLE 3.

Correlations between log10 plasma neurofilament light levels with age and measures of clinical severity at time points 1 and 2 in individuals with Wolfram syndrome.

	NfL TP 1 vs. Clinical TP 1	N	NfL TP 1 vs. Clinical TP 2	N	NfL TP 2 vs. Clinical TP 2	N
Age	r = 0.21, p = 0.21	38	r = 0.23, p = 0.25	27	r = 0.30, p = 0.13	27
WURS Physical Activity subscore total	ρ = –0.14, p = 0.40	34	ρ = –0.07, p = 0.72	26	ρ = 0.10, p = 0.63	26
UPSIT (number correct)	r = –0.26, p = 0.12	37	r = –0.38, p = 0.05*	27	r = –0.46, p = 0.02*	27
Visual acuity (logMAR)	r = 0.34, p = 0.05*	34	r = 0.40, p = 0.04*	27	r = –0.46, p = 0.02*	27
Color vision (number correct)	r = –0.40, p = 0.03*	30	r = –0.42, p = 0.07	20	r = –0.59, p = 0.01**	20
Ventral pons volume	r = –0.24, p = 0.23	27	r = –0.34, p = 0.14	21	r = –0.35, p = 0.12	21
Brainstem volume	r = –0.48, p = 0.04*	18	r = –0.50, p = 0.04*	18	r = –0.43, p = 0.08	18
Cerebellar cortex volume	r = 0.12, p = 0.55	26	r = 0.21, p = 0.37	20	r = 0.25, p = 0.29	20
Thalamic volume	r = –0.36, p = 0.07	26	r = –0.60, p = 0.01**	20	r = –0.57, p = 0.01**	20
Average annual rate of change in thalamic volume	NA		r = –0.52, p = 0.01**	24	NA

NfL, neurofilament light chain; TP, time point; WURS, Wolfram Unified Rating Scale; UPSIT, University of Pennsylvania Smell Identification Test; NA, not applicable. *, **p ≤ 0.05, 0.01. Bold p-values indicate statistical significance at α = 0.05. N = number of participants with data points included in the analysis in the preceding column.