. 2022 Apr 24;10(4):e003472. doi: 10.1136/jitc-2021-003472

Table 1.

Phenotypic and functional heterogeneity of T_RM cells across organs

Localization		Phenotype	Functional characteristics	Reference
CD8 T_RM
Gut	mice	Id3^low Blimp1^high		50
	mice	Id3^high Blimp1 ^low		50
	Human	CD103⁺CD69⁺	Highly polyfunctional (IFN-γ⁺/IL-2⁺/TNF-α⁺)	51
	Human	β2integrin⁺CD103⁻CD69⁺	Highly cytotoxic (GZMB⁺)
	IE	CD103⁺ KLRG1^- CD28 ^low 2B4 ^high CD161^high CD127^high PD-1^low	Damped polyfunctionality Damped cytotoxicity	40
	LP	CD103⁺ KLRG1^- CD28^low 2B4 ^high CD161^high CD127 ^high PD-1^low	Highly polyfunctional (IFN-γ⁺/IL-2⁺/TNF-α⁺) GZMB⁺, Perforin⁺
		CD103^- KLRG1^- CD28^high CD161^low CD127^low PD-1 ^high NKG2D ^high	Polyfunctional (IFN-γ⁺/IL-2⁺/TNF-α⁺)
		CD103^- KLRG1⁺ CD28 ^high CD161 ^low CD127 ^low PD-1 ^high NKG2D ^high	Highly cytotoxic (GZMB⁺, Perforin⁺)
Liver	mice	CD69⁺ CD103^-	Highly polyfunctional (IFN-γ⁺/IL-2⁺/TNF-α⁺)	55
	Human	CD69⁺CD103⁺ CXCR6⁺ CXCR3⁺	High IL-2 production	11
Pancreas	Human	CD69⁺ CD103⁺ CD49a⁺ CD101⁺ PD-1⁺	GZMB⁺ Highly polyfunctional (IFN-γ⁺/IL-2⁺)	16
Skin	mice	CD69⁺ CD103⁺	Damped polyfunctionality (IFN-γ⁺/IL-2⁺/TNF-α⁺)	55
Skin		CD69⁺ CD103⁺ CD49a⁺	Increased IFN-γ production	37
Salivary gland	mice	CD69⁺ CD103^- CD69⁺ CD103⁺	Highly polyfunctional (IFN-γ⁺/IL-2⁺/TNF-α⁺) Damped polyfunctionality (IFN-γ⁺/IL-2⁺/TNF-α⁺)	55
Lymph nodes	human	CD69⁺ CD103^-	IFN-γ⁺, IL-2⁺	16
CD4 T_RM
Liver	human	CD69 ^high CXCR6⁺ CD49a⁺ PD-1⁺ S1PR1^- CD69 ^int CXCR3⁺ CX3CR1⁺ CXCR1⁺	TH1 cytokine production (IL-2, IFN-γ, IL-21) TH2 cytokine production (IL-4)	56
Small intestine	human	CD69⁺ CD103⁺ 2B4⁺ CD49a⁺ CXCR6⁺ CD101⁺ CD161⁺ CD28^low CD69⁺ CD103^- KLRG1⁺ CD49a⁺ CXCR6⁺ CD101⁺ CD161⁺ CD28^low	TH1 cytokine production (IFN-γ⁺/IL-2⁺/TNF-α⁺) GZMB⁺, Perforin⁺, IL-17⁺ TH1 cytokine production (IFN-γ⁺/IL-2⁺/TNF-α⁺) Perforin⁺	57

IE, Intra-epithelial; LP, lamina propria.