Table 2.

Distribution of C3 genotypic and haplotypic variants.

Genotype/haplotype	Amino acid	Aparasitemic	UM (Hb ≥ 5.0 g/dL)	SMA (Hb < 5.0 g/dL)	Total	P
2307C>G (rs2230199)	Arg>Gly102	n = 300	n = 1008	n = 303	n = 1611
CC, n (%)	Arg/Arg102	223 (74.33)	824 (81.75)	240 (79.21)	1287 (79.89)
CG, n (%)	Arg/Gly102	69 (23.00)	173 (17.16)	56 (18.48)	298 (18.50)	0.027
GG, n (%)	Gly/Gly102	8 (2.67)	11 (1.09)	7 (2.31)	26 (1.61)
34420G>A (rs11569534)	Gly>Asp1224	n = 299	n = 1002	n = 302	n = 1603
GG, n (%)	Gly/Gly1224	268 (89.63)	893 (89.12)	259 (85.80)	1420 (88.58)
GA, n (%)	Gly/Asp1224	23 (7.70)	56 (5.59)	26 (8.60)	105 (6.55)	0.078
AA, n (%)	Asp/Asp1224	8 (2.67)	53 (5.29)	17 (5.60)	78 (4.87)
2307C>G/34420G>A	Arg>Gly102/Gly>Asp1224	n = 302	n = 1009	n = 306	n = 1617
Non-CG, n (%)	Non-Arg102Non-Gly1224	19 (6.29)	73 (7.23)	33 (10.78)	125 (7.73)	0.084
CG, n (%)	Arg102Gly1224	283 (93.71)	936 (92.77)	273 (89.22)	1492 (92.27)
Non-CA, n (%)	Non-Arg102Asp1224	271 (89.74)	902 (89.40)	263 (85.95)	1436 (88.81)	0.216
CA, n (%)	Arg102Asp1224	31 (10.26)	107 (10.60)	43 (14.05)	181 (11.19)
Non-GG, n (%)	Non-Gly102Gly1224	225 (74.50)	839 (83.15)	244 (79.74)	1308 (80.89)	0.004
GG, n (%)	Gly102Gly1224	77 (25.50)	170 (16.85)	62 (20.26)	309 (19.11)
Non-GA, n (%)	Non-Gly102Asp1224	302 (100.00)	995 (98.61)	305 (99.67)	1602 (99.07)	0.048
GA, n (%)	Gly102Asp1224	0 (0.00)	14 (1.39)	1 (0.33)	15 (0.093)

Data are presented as proportions [n (%)] of genetic variants within the study groups. Study participants were categorized into three groups, aparasitemic, SMA (i.e., Hb < 5.0 g/dL with any density parasitemia) or UM (Hb ≥ 5.0 g/dL with any density parasitemia). Statistical significance determined by Fisher’s exact test. Boldface indicates a values of P < 0.05.