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. 2022 Jan 20;9:rbac002. doi: 10.1093/rb/rbac002

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Yap regulates inflammation-related genes transcriptionally. (A) IL6 and IL6R peaks where Yap binds to the promoter or enhancer, respectively. (B) Validation by ChIP-qPCR analysis of Yap binding to IL6 in Mg-ECs. (C) qRT–PCR analysis of IL6 in Mg-ECs. (D) ChIP-qPCR analysis of Yap binding to the promoter of inflammation-related transcriptional factors. (E) ChIP-qPCR analysis of Yap binding to the promoter of inflammation-related co-transcriptional factors. Data are presented as mean ± SD, P-values were calculated according to a two-tailed unpaired t-test or two-way analysis of variance. **P < 0.05, **P < 0.01, ^***P < 0.001