FIG. 4.
AUC/MIC ratio-dependent endpoints of the antimicrobial effect of gemifloxacin fitted by equations 1 (ABBC, AUGC, and AUGCE), 2 (AUBC and AAC), and 3 (IE ≡ ABBCE, AACE; and AUBCE). IE ≡ ABBCE, a = −187 and b = 164; ABBC; Emax = 137, x50 = 1.54, and s = 8.38; AUGC, Emax = 65, x50 = 1.55, and s = 8.36; AUGCE; Emax = 59, x50 = 1.25, and s = 7.05; AAC, Emax = 71, Emin = −77, x50 = 1.51, and dx = 0.2; AACE, a = −93 and b = 79; AUBC, Emax = 219, Emin = 76, x50 = 1.53, and dx = 0.2; AUBCE, a = −50 and b = 78. The therapeutic range of AUC/MIC ratios is indicated by the shaded area.