Table 5.

Menadione alkylation with amino acids by Naturale’s group.

Entry	Amino acid	Product	Protective group	Conversion (%)	Yield (%)
1		92a	Boc	74	40
		92b	Troc	89	58
		92c	Ac	98	49
		92d	TFA	100	42
2		89a	Boc	96	58
		92e	Troc	100	42
		92f	Ac	57	13
		92g	TFA	100	51
3		89b	Boc	88	61
		92h	Troc	86	60
		92i	Ac	75	54
		92j	TFA	98	53
4		92k	Boc	0	0
		92l	Troc	35	18
		92m	Ac	29	16
		92n	TFA	92	27
5		92o	Boc	0	0
		92p	Troc	42	34
		92q	Ac	24	24
		92r	TFA	29	29
6		92s	Boc	100	50
		92t	Troc	100	55
		92u	Ac	93	57
		92v	TFA	100	39