TABLE 1.
Baseline characteristics of patients and outcome by treatment group in a controlled study of 3-day quinine-clindamycin treatment versus 7-day quinine treatment in patients returning to France from the tropics with uncomplicated falciparum malaria
| Characteristic | 7-day quinine treatment | 3-day quinine-clindamycin treatment |
|---|---|---|
| Patients (no.) | 55 | 53 |
| Males (no.) | 36 | 36 |
| Age (yr) | 35 (43)a | 35 (46)a |
| Parasitemia (μl/ml) | 2,000 (12,600)a | 3,600 (12,000)a |
| Lost to follow-up (no. of patients) | 1 | 2 |
| Adequate clinical response (ITT) (% [95% CI]) | 94.6 (84.9–98.9) | 96.2 (87–99.6) |
| Failure (no. of patients) | ||
| Early | 2b | 0 |
| Late | 0 | 0 |
| Fever clearance time (h) | ||
| Median | 52 | 43 |
| Range | 102 | 91 |
| Interquartile range | 50 | 42 |
| Parasite clearance time (days) | ||
| Median | 3 | 3 |
| Range | 4 | 4 |
| Interquartile range | 1 | 1 |
a
Data are medians interquatile ranges.
b
Severe side effects led to unblinding and the cessation of treatment.