Table 2.
Novel mutations identified in the spike protein of the recently emerged Omicron subvariants (emerged before 15 January 2022; frequency > 50 sequences)
| Spike region | Position | New Mutation | Frequency | Percentage | Mutation in VOCs & VOIs | Early event occurrence time | First country emerging | |
|---|---|---|---|---|---|---|---|---|
| S1 | – | 5 | L5F | 184 | 0.37% | Iota(L5F) | 2021.11.19 | South Africa |
| NTD | 76 | T76I | 51 | 0.10% | Lambda (T76I) | 2021.11.26 | Netherlands | |
| 141 | L141F | 56 | 0.11% | – | 2021.11.19 | South Africa | ||
| 142 | G142Y | 51 | 0.10% | – | 2021.12.16 | USA | ||
| 156 | deletion | 68 | 0.14% | Delta(del156) | 2021.12.13 | USA | ||
| 157 | deletion | 71 | 0.14% | Delta(del157) | 2021.12.13 | USA | ||
| 158 | R158G | 69 | 0.14% | Delta(E158G) | 2021.12.15 | USA | ||
| RBD | 346 | R346K | 16819 | 33.90% | Mu(R346K) | 2021.11.4 | Canada | |
| 452 | L452R | 897 | 1.81% | Delta(L452R) | 2021.11.11 | South Africa | ||
| SD | 643 | F643L | 138 | 0.28% | – | 2021.11.29 | Thailand | |
| 681 | P681R | 62 | 0.12% | Delta(P681R) | 2021.11.23 | Botswana | ||
| S2 | – | 701 | A701V | 2729 | 5.50% | Beta(A701V) | 2021.11.10 | South Africa |
| – | 1081 | I1081V | 351 | 0.71% | – | 2021.11.18 | U.K. | |
| 1147 | S1147L | 120 | 0.24% | – | 2021.12.13 | USA | ||
| 1162 | P1162S | 60 | 0.12% | – | 2021.12.10 | Canada | ||