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. 2022 Apr 12;9:840648. doi: 10.3389/fnut.2022.840648

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Copyright © 2022 Wang, Xu, Yu, Liu, Ma, Ji, Zhang, Xue, Li and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological changes of ATX on liver and epididymal fat in HFD-induced mice. (A) Liver sections stained with HE (200×, 400×). (B) Liver sections stained with Oil red O (200×, 400×). (C) HE-stained e-AT sections (200×). (D) Steatohepatitis scores. (E) Percentage of the lipid droplet area assessed by Oil red O staining. (F) Mean cell area of adipocyte in e-AT. Values are expressed as mean ± SD of triplicate (n = 6). The different letters (a–d) indicate significant differences (P < 0.05) according to Duncan’s multiple range test in ANOVA.