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. 2022 Apr 12;9:840648. doi: 10.3389/fnut.2022.840648

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Copyright © 2022 Wang, Xu, Yu, Liu, Ma, Ji, Zhang, Xue, Li and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Astaxanthin regulated lipid metabolites in HFD-fed mice. (A) OPLS-DA score plot (left) and permutation plot (right). (B) Venn diagram depicting the overlap of significantly changed metabolites between experimental groups. The volcano plot analysis of ND vs. HFD group (C) and HFD vs. HFD + 0.75% ATX group (D). Analysis of lipid metabolism pathway of ND vs. HFD (E) and HFD vs. HFD + 0.75% ATX (F). (G) Heatmap of 34 significantly altered metabolites in ATX-treated HFD-fed mice. Blue: downregulated metabolites. Red: upregulated metabolites. (H) The associated heatmap of significantly changed metabolites.