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. 2022 Apr 12;13:836492. doi: 10.3389/fimmu.2022.836492

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Copyright © 2022 Stebbings, Jones, Cotton, Armour, Maguire, Skellett, Tang, Goodman, Brady, Takahashi, Daunt, Lapointe and Cohen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The S1 subunit of the SARS-CoV-2 spike glycoprotein is cleaved in vitro following AZD1222 transduction. (A) Viability of HEK293x cell lines 48 and 72 hours following transduction with AZD1222 at increasing input MOIs or ChAdOx1-GFP control. Error bars show the associated standard deviation for each sample. (B) Expression of SARS-CoV-2 S1 and S2 spike protein subunits 48 or 72 hours post transduction with AZD1222. (C) Expression of GFP control 48 or 72 hours post transduction with ChAdOx1-GFP. (D) Levels of SARS-CoV-2 S1 subunit and (E) full-length spike protein in cell culture supernatants at 48- and 72-hours post-transduction.