Table 2.
Effects on host immune response and hematology parameters immediately following AZD1222 immunization.
| Platelets (109/L) | Total White Blood Cells (109/L) | Neutrophils (109/L) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Hours post-AZD1222 immunization | Vehicle | IV 1x109 VP | IM 1x1010 VP | Vehicle | IV 1x109 VP | IM 1x1010 VP | Vehicle | IV 1x109 VP | IM 1x1010 VP |
| 0 | 1033.0 | – | – | 6.933 | – | – | 0.840 | – | – |
| 2 | NA | – | – | NA | – | – | NA | 2.940↑ | – |
| 12 | NA | – | 753.5↓ | NA | 1.593↓ | 1.040↓ | NA | – | – |
| 24 | NA | 868.0↓ | – | NA | 1.913↓ | 3.267↓ | NA | – | – |
| 48 | NA | 721.3↓ | – | NA | – | – | NA | – | – |
| 72 | NA | 815.3↓ | – | NA | – | – | NA | – | – |
| 166 | NA | – | – | NA | – | – | NA | – | – |
| 336 | 1295.0 | – | – | 6.977 | – | – | 0.890 | – | – |
Values presented are group mean absolute values that were outside of the reference ranges observed in mice under similar study conditions at concurrent and non-concurrent timepoints from historical control data for the testing facility.
IM, intramuscular; IV, intravenous; NA, Not applicable; VP, viral particles; – = Group mean value was within the reference range, indicating no AZD1222-related change; ↓ = decreased versus reference range; ↑ = increased versus reference range.