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. 2022 Apr 12;12:844477. doi: 10.3389/fonc.2022.844477

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Copyright © 2022 Ning, Sun, Su, Tan, Tang, Sayed, Li, Xue, Liu, Chen and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing Tip60 or treatment with Tip60 inhibitors downregulate the level of β-catenin acetylation at K49 in colon cancer cells. (A, B) SW480 (A) and HCT116 (B) cells were infected with shNC, shTip60-1 and shTip60-2 lentivirus, respectively. The expression of β-catenin, acetylated β-catenin at K49, CK1δ, CK1ϵ and GAPDH was measured by immunoblotting. (C, D) SW480 (C) and HCT116 (D) cells were serum-starved for 12 h and subsequently treated with the indicated amounts of MG149 for 12 h Cell lysates were subjected to immunoblotting with the indicated antibodies. (E, F) Similar to panel (C, D) except that the indicated concentrations of NU9056 were used.