Fig. 10.

Dup(Rno20)Yah rats exhibit suppressed recognition memory that is restored by CBS inhibition. (A): Schematic representation of the object-location recognition paradigm. (B): The time allotted in exploring the objects available in the apparatus during the 5-min acquisition trial. (C): Representative tracking maps that are annotated with all acquired positions of the animal in the arena in dark purple along with the path followed in the novel and familiar locations in light orange and blue colors, respectively. (D): The Recognition Index for the novel object location, calculated as the percent ratio of the time spent in the novel location of the object over the total exploration time and assessed during the retention trial. Each dot plot represents one animal. Each bar represents the mean ± SEM of 11 independent rats per experimental condition. Data were analyzed with two-way ANOVA analysis followed by post hoc Bonferroni's multiple comparison t-tests. **p≤0.01 shows significant differences between saline-treated DS rats and saline-treated WT rats; ^#p ≤ 0.05 shows significant effect of AOAA treatment in Dup(Rno20)Yah rats, indicative of restoration of recognition memory of these animals. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)