Fig. 9.

Dup(Rno20)Yah rats exhibit normal locomotion and exploratory behavior. (A): Schematic representation of the open field arena annotated with the areas of interest used for assessing the emotional status and exploratory/risk-taking behaviors. (B): The total distance traveled along with (C): % thigmotaxis – which defines the percentage of time allotted in hanging in corner areas – per minute was monitor over the 10-min arena familiarization session. (D): Representative tracking maps annotated with all acquired positions of the animal in the arena in dark purple and the path followed in the center in light purple. (E): The total number along with the (F) total time spent in the center of the arena were monitored to evaluate exploratory/risk-taking behavior in this animal-aversed zone. Each dot plot represents one animal. Each symbol represents the mean ± SEM of 11 rats per experimental condition. No significant differences were noted between any of the experimental groups studied. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)