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. 2021 Aug 20;10(2):273–283. doi: 10.14218/JCTH.2021.00010

Table 4. Twenty-three genes for calculation of the mHPS.

Gene symbol Gene ID Full name High score Low score Weight
RALA 5,898 RAS like proto-oncogene A 0 1 3.6386383
PLOD2 5,352 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 0 1 4.571733
PPT1 5,538 Palmitoyl-protein thioesterase 1 0 1 3.6378715
CTSC 1,075 Cathepsin C 0 1 2.929253
ETV5 2,119 ETS variant transcription factor 5 0 1 3.15026
ALDOA 226 Aldolase, fructose-bisphosphate A 0 1 3.5781527
ARPC2 10,109 Actin related protein 2/3 complex subunit 2 0 1 3.4750159
SLC38A1 81,539 Solute carrier family 38 member 1 0 1 4.9902163
TM4SF1 4,071 Transmembrane 4 L six family member 1 0 1 3.6512656
PFKFB3 5,209 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0 1 4.242654
RGN 9,104 regucalcin 1 0 3.4342885
EPHX2 2,053 epoxide hydrolase 2 1 0 4.14249
IQGAP2 10,788 IQ motif containing GTPase activating protein 2 1 0 3.2472568
SLC22A7 10,864 Solute carrier family 22 member 7 1 0 3.2640932
CYP27A1 1,593 cytochrome P450 family 27 subfamily A member 1 1 0 3.2004652
COBLL1 22,837 cordon-bleu WH2 repeat protein like 1 1 0 3.4549387
CYP4F12 66,002 cytochrome P450 family 4 subfamily F member 12 1 0 4.133354
APOC3 345 Apolipoprotein C3 1 0 3.7753599
CDO1 1,036 Cysteine dioxygenase type 1 1 0 3.1609652
PAH 5,053 Phenylalanine hydroxylase 1 0 3.727815
ITPR2 3,709 Inositol 1,4,5-trisphosphate receptor type 2 1 0 3.3972855
SERPINA10 51,156 Serpin family A member 10 1 0 3.569119
SLC2A2 6,514 Solute carrier family 2 member 2 1 0 2.9978447

For genes with blue color in Figure 2E, patients with low expression (below the median) are assigned a score of 1. Conversely, for genes with red color in Figure 2E, patients with high expression (above the median) are assigned a score of 1.