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. 2022 Apr 12;10:861006. doi: 10.3389/fcell.2022.861006

TABLE 2.

Studies reporting combined biological effects of hypomagnetic field and microgravity in mammals.

Studied materials Experimental treatments Combined biological effects Refs
8-week-old male C57BL/6 mice HMF (<300 nT)-HLU (4 weeks) Accumulation of iron, bone loss and negative effect on the biomechanical properties of the femur Yang et al. (2018)
Weighing 260 ± 10 g male SD rats HMF (<300 nT)-HLU (4 weeks) Expression of RANKL and serum iron concentration increase Jia et al. (2014)
6-week-old male C57BL/6 mice HLU (4 weeks) + HMF (<300 nT, 4 weeks) Lower bone mineral content, iron accumulation, unbalanced bone remodeling Xue et al. (2020b)
Weighing 260 ± 10 g male SD rats HMF (<300 nT)-HLU (4 weeks) The dielectric properties of the gastrocnemius muscle are smaller than that of both alone Ding et al. (2014b)
Human bronchial epithelial cells BEAS-2B HMF (<50 nT, 1 week) + X-rays (2, 4, 6 Gy) Cell survival increase, less DNA damage and more efficient damage repair Xue et al. (2020a)

“+”: sequential treatments; “-”: simultaneous treatments.