Figure 2.

YAP deletion in HBCs impairs OE regeneration and functional recovery of the olfactory system after injury

(A) H&E staining of the OE obtained from 2-month-old YAP^f/f and YAP^K5-CKO mice at 0, 3, 5, 14, and 28 dpl.

(B) Quantitative analysis of the thickness of OE as shown in (A) (n = 10 sections from 5 mice per group).

(C) Percentage of mice that found cookies over total observed 2-month-old YAP^f/f (n = 9 mice) or YAP^K5-CKO mice (n = 10 mice) in the buried pellet test at 0, 3, 5, 10, 14, and 28 dpl.

(D) Quantitative analysis of the time to locate food of 2-month-old YAP^f/f (n = 9 mice) and YAP^K5-CKO mice (n = 10 mice) at 0, 3, 5, 10, 14, and 28 dpl in the buried pellet test.

Data are mean ± SEM, two-way ANOVA with Bonferroni’s post tests, compared with YAP^f/f group; ^∗∗p < 0.01, ^∗∗∗p < 0.001. Scale bars, 20 μm.