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. 2022 Feb 10;17(3):664–677. doi: 10.1016/j.stemcr.2022.01.007

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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YAP deletion in HBCs reduces the regeneration of OSNs after OE injury

(A) Double immunostaining of GAP43 (green) and OMP (red) in the OE of 2-month-old YAP^f/f and YAP^K5-CKO mice at 0, 7, and 14 dpl.

(B and C) Quantitative analysis of the density of GAP43⁺ (B) or OMP⁺ (C) cells in the OE of 2-month-old YAP^f/f and YAP^K5-CKO mice at 0, 3, 7, 14, and 28 dpl (n = 9 sections from 5 mice per group).

(D) Immunostaining of Sox9 (green) in the OE of 2-month-old YAP^f/f and YAP^K5-CKO mice at 0 and 14 dpl.

(E) Quantitative analysis of the density of Sox9⁺ cells as shown in (D) (n = 11 sections from 5 mice per group).

(F) Immunostaining of OMP (red) in the OB of 2-month-old YAP^f/f and YAP^K5-CKO mice at 0, 7, and 14 dpl. EPL, external plexiform layer; GL, glomerular layer.

(G) Quantitative analysis of the percentage of area that showed OMP⁺ area over granule cell layer (GCL) area as shown in (F) (n = 11 sections from 5 mice per group).

Images of selected regions are shown at higher magnification. Data are mean ± SEM, two-way ANOVA with Bonferroni’s post tests, compared with YAP^f/f group; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. Scale bars, 20 μm.