Table 2.
Main characteristics at diagnosis of native kidney or liver cyst infection in 21 patients ADPKD with functional renal allografts at diagnosis
| Kidney transplant patient n = 21/episodes = 22 | |
|---|---|
| Clinical features | |
| Age-yr | 61 (9) |
| Male | 10/21 (48%) |
| Atypical clinical signs | 7 (32%) |
| Lack of fever | 2 (9%) |
| Isolated fever | 5 (23%) |
| Severe sepsis/septic shock | 3 (14%) |
| Laboratory findings | |
| Leukocyte (G/l) | 8.3 (4) |
| Polynuclear neutrophils (G/l) | 5.5 (2.6) |
| C-reactive protein (mg/l) | 161 (29) |
| Acute kidney injury | 12 (55%) |
| AKIN 1 | 6/12 (50%) |
| AKIN 2 | 2/12 (17%) |
| AKIN 3 | 4/12 (33%) |
| Positive imaging exams | |
| Ultrasound | 3/19 (16%)a |
| CT scan | 5/12 (33%)a |
| PET-CT | 14/16 (87%) |
| Location of cyst infection | 19 (86%) |
| Native kidney | 12/19 (63%) |
| Liver | 7/19 (37%) |
| Microbiological features | |
| Positive culture | 16 (73%) |
| Cyst fluid | 2b |
| Blood culture | 8b |
| Urine culture | 9b |
| Microbial identification | |
| Gram-negative bacilli | 13/16 (81%) |
| Escherichia coli | 8 (50%) |
| Othersc | 5 (31%) |
| Gram positive bacteriad | 4/16 (25%) |
| Enterococcus faecalis | 2 (13%) |
| Streptococcus species | 2 (13%) |
ADPKD, autosomal dominant polycystic kidney disease; CT, computed tomography; PET, positron emission tomography.
Continuous variables were summarized as mean and SD, and categorical and ordinal variables were summarized as frequencies and percentages.
In 2 episodes with positive ultrasound features and 1 episode with positive CT scan features for cyst infection, a PET-CT was also performed, confirming the location of cyst infection.
Two patients had both positive blood and urine culture, and 1 patient had both positive cyst fluid and blood culture.
Morganella morganii n =1, Klebsiella oxytoca n =1, Pseudomonas aeruginosa n = 1, Bacillus licheniformis and Enterobacter cloacae n = 1
One patient had multibacterial cyst infection with both Escherichia.coli and Enterococcus faecalis.