Ferguson 1953.

Methods	Alternate allocation, placebo controlled trial. 190 received DES and 203 had placebos.
Participants	All women attending antenatal clinic.
Interventions	DES 6.3 mg to 137.5 mg depending on gestational age vs placebo.
Outcomes	Miscarriages, pre‐eclampsia, chronic hypertension with superimposed pre‐eclampsia, duration of pregnancy, weight gain and oedema, prematurity, stillbirth and neonatal deaths, fetal abnormality, threatened miscarriage, toxic reactions, placental effect.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	High risk	C ‐ Inadequate