Ferguson 1953.
Methods | Alternate allocation, placebo controlled trial. 190 received DES and 203 had placebos. | |
Participants | All women attending antenatal clinic. | |
Interventions | DES 6.3 mg to 137.5 mg depending on gestational age vs placebo. | |
Outcomes | Miscarriages, pre‐eclampsia, chronic hypertension with superimposed pre‐eclampsia, duration of pregnancy, weight gain and oedema, prematurity, stillbirth and neonatal deaths, fetal abnormality, threatened miscarriage, toxic reactions, placental effect. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | High risk | C ‐ Inadequate |