Table 1.
Clinical features of patients with adult-onset Still’s disease by age group.
| Younger-onset (n = 36) < 65 years | Elderly onset (n = 26) ≥ 65 years | p | |
|---|---|---|---|
| Demographic features | |||
| Female | 23 (63.9%) | 19 (73.1%) | 0.44 |
| Age at onset (years) | 44.5 ± 11.4 | 74.7 ± 5.4 | < 0.001 |
| Interval between onset and treatment (months) | 1.0 (0.75–1.0) | 1.0 (0.25–2.0) | 0.67 |
| Having any comorbidities | 8 (22.2%) | 12 (46.2%) | 0.046 |
| Clinical symptoms | |||
| Fever (≥ 39 °C, lasting 1 week or longer) | 36 (100%) | 26 (100%) | – |
| Arthralgia (lasting 2 weeks or longer) | 33 (91.7%) | 23 (88.5%) | 0.67 |
| Skin rash | 29 (80.6%) | 23 (88.5%) | 0.40 |
| Typical skin rash | 21 (58.3%) | 14 (53.8%) | 0.72 |
| Sore throat | 31 (86.1%) | 14 (53.8%) | 0.004 |
| Lymphadenopathy | 20 (55.6%) | 13 (50.0%) | 0.66 |
| Splenomegaly | 19 (52.8%) | 10 (38.5%) | 0.26 |
| Pericarditis | 5 (13.9%) | 2 (7.7%) | 0.44 |
| Pleuritis | 6 (16.7%) | 12 (46.2%) | 0.011 |
| Interstitial pneumonitis | 1 (2.8%) | 2 (7.7%) | 0.37 |
| Abdominal pain | 3 (8.3%) | 2 (7.7%) | 0.92 |
| Myalgia | 4 (11.1%) | 4 (15.4%) | 0.62 |
| Pouchot’s score | 5.0 (4.0–6.25) | 5.0 (4.0–6.0) | 0.54 |
| Complications | |||
| DIC | 3 (8.3%) | 8 (30.8%) | 0.022 |
| Macrophage activation syndrome | 1 (2.8%) | 5 (19.2%) | 0.03 |
| Amyloidosis | 0 (0%) | 0 (0%) | - |
| Laboratory findings | |||
| White blood cells (/mm3) | 13,125 (10,115–15,990) | 14,765 (10,852–20,070) | 0.25 |
| Neutrophils (%) | 87.4 (82.7–89.0) | 89.0 (84.0–92.6) | 0.093 |
| Hemoglobin (g/dl) | 11.7 (10.9–12.8) | 10.9 (9.9–12.0) | 0.031 |
| Platelet (× 103/mm3) | 22.5 (15.6–30.6) | 26.6 (13.5–37.8) | 0.48 |
| ESR (mm/h) | 84.0 (26.0–94.0) | 88.0 (67.0–107.0) | 0.10 |
| CRP (mg/dl) | 10.5 (5.8–12.9) | 14.9 (9.8–21.1) | 0.021 |
| Ferritin (ng/ml) | 7187 (1781–16,106) | 15,036 (2449–25,746) | 0.097 |
| AST (IU/L) | 58 (40–85) | 62 (46–88) | 0.39 |
| ALT (IU/L) | 45 (31–98) | 40 (22–68) | 0.31 |
| Blood urea nitrogen (mg/dl) | 12.2 (9.2–16.0) | 13.0 (11.0–18.4) | 0.18 |
| Creatinine (mg/dl) | 0.61 (0.55–0.68) | 0.63 (0.48–0.82) | 0.98 |
| Triglyceride | 162 (114–217) | 135 (114–175) | 0.37 |
| Fibrinogen | 363 (226–474) | 417 (168–580) | 0.39 |
| Positive RF | 4 (11.1%) | 3 (11.5%) | 0.95 |
| Positive ANA | 5 (13.9%) | 4 (15.4%) | 0.86 |
Data are presented as number (%), mean ± standard deviation or median (interquartile range).
p < 0.05, are represented in bold.
DIC disseminated intravascular coagulation, ESR erythrocyte sedimentation rate, CRP C-reactive protein, AST aspartate aminotransferase, ALT alanine aminotransferase, RF rheumatoid factor, ANA anti-nuclear antibody.