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. 2022 Apr 26;12:6787. doi: 10.1038/s41598-022-10932-3

Table 2.

Treatment and outcomes of patients with adult-onset Still’s disease by age group.

Younger-onset (n = 36) < 65 years Elderly onset (n = 26) ≥ 65 years p
Treatment
GCs 35 (97.2%) 26 (100%) 0.39
Maximal dose (mg/kg/day) 0.88 ± 0.26 0.93 ± 0.29 0.47
GCs pulse therapy 26 (72.2%) 20 (76.9%) 0.67
GCs pulse therapy ≥ 3 times 7 (19.4%) 7 (26.9%) 0.48
Time until GCs dose was halved (days) 60.7 ± 25.3 72.8 ± 53.8 0.26
GCs only 11 (30.6%) 12 (46.2%) 0.20
Methotrexate 12 (33.3%) 6 (23.1%) 0.37
Tacrolimus 6 (16.7%) 2 (7.7%) 0.11
Cyclosporine 13 (36.1%) 12 (46.2%) 0.42
Tocilizumab 8 (22.2%) 7 (26.9%) 0.66
Tumor necrosis factor-α inhibitors 1 (2.8%) 1 (3.8%) 0.81
Plasma exchange 11 (30.6%) 4 (15.4%) 0.16
Infection
Cytomegalovirus 5 (13.9%) 10 (38.5%) 0.025
Others 4 (11.1%) 4 (15.4%) 0.62
Relapse 11 (30.6%) 10 (38.5%) 0.51
Death 1 (2.8%) 2 (7.7%) 0.37

Data are presented as numbers (%) or mean ± standard deviation.

p < 0.05, are represented in bold.

GC glucocorticoid.