Table 1.

Hierarchical clustering of TRs associated with different types of therapies.

Cluster	Characteristic of TRs
1	TRs with RePhine correlation to most MAPK inhibitors such as PLX4720 and erlotinib
2	TRs with positive RePhine correlation to chemotherapy drugs and cell cycle inhibitors
3	TRs with comparatively moderate RePhine correlation to drugs
4	TRs with positive RePhine correlation to EGFR inhibitors but with negative correlation to ABL and ALK inhibitors
5	TRs with positive RePhine correlation to EGFR inhibitors and MEK inhibitors but with negative correlation to chemotherapy drugs and CDK inhibitors

Note: TR, transcriptional regulator; MAPK, mitogen-activated protein kinase; EGFR, epidermal growth factor receptor; ABL, Abelson tyrosine kinase; ALK, anaplastic lymphoma kinase; MEK, mitogen-activated protein kinase kinase; CDK, cyclin-dependent kinase.