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Proposed mechanism of protective mechanism underlying F1 HF diet-induced decrease in FGF21 via regulation of KDM4C. F1 HF diet-induced reduction in beige adipocyte and FGF21 is minimized by reducing G9a by F1 exercise by increasing KDM4C expression which reduces methylation of H9K9 thereby reducing G9a, an inhibitor of FGF21.
