Fig. 3.

Ubiquitination of MHC II and CD86 by MARCH1 and MARCH8 in granulocytes and monocytes. Surface expression of MHC II and CD86 in neutrophils, eosinophils and inflammatory and patrolling monocytes purified from (A) spleen and (B) lung of WT mice or mice deficient in I-Aα, MARCH1, or MARCH8. Bars represent mean ​± ​SD with each symbol representing an individual mouse (n ​= ​5). Statistical analysis was performed using one-way ANOVA followed by Sidak's multiple comparisons test. ∗∗∗∗p ​< ​0.0001, ∗∗p ​< ​0.002, n.s. not significant.