Table 3.

Adjusted HRs for Cardiovascular Outcomes by Cancer Status: Primary and Sensitivity Analyses

	All-Cause Mortality	CV Mortality	Acute MI	Stroke	Heart Failure	Pulmonary Embolism
Weibull RCS (primary)
Cancer (reference no cancer)	8.34 (8.26-8.42)	1.33 (1.29-1.37)	1.01 (0.97-1.05)	1.44 (1.41-1.47)	1.62 (1.59-1.65)	3.43 (3.37-3.50)
Competing risks (sensitivity)
Cancer (reference no cancer)			1.05 (1.01-1.09)	1.40 (1.38-1.43)	1.79 (1.75-1.82)	2.77 (2.72-2.82)
Cox (sensitivity)
Cancer (reference no cancer)	8.34 (8.26-8.42)	1.33 (1.29-1.37)	1.01 (0.97-1.04)	1.44 (1.41-1.47)	1.62 (1.59-1.65)	3.43 (3.37-3.50)
Age and sex 1:1 matched (sensitivity)
Cancer (reference no cancer)	12.92 (12.72-13.13)	1.73 (1.67-1.80)	1.03 (0.99-1.08)	1.38 (1.35-1.41)	1.59 (1.55-1.62)	3.13 (3.05-3.20)
Exclude participants diagnosed with stage 0 cancer (sensitivity)
Cancer (reference no cancer)	9.22 (9.13-9.31)	1.36 (1.32-1.40)	1.03 (0.99-1.07)	1.49 (1.46-1.52)	1.69 (1.66-1.73)	3.97 (3.89-4.04)

Values are HR (95% CI). Reference group is the no-cancer group in all rows (HR: 1.00). Fully adjusted for baseline age, biological sex, neighborhood material deprivation quintile, rural or urban, distance to cancer center, and distance to family doctor, plus 31 comorbidities: alcohol misuse, asthma, atrial fibrillation, heart failure, severe chronic kidney disease, chronic pain, chronic pulmonary disease, dyslipidemia, viral hepatitis B, cirrhosis, severe constipation, dementia, depression, diabetes mellitus, epilepsy, gout, hypertension, hypothyroidism, inflammatory bowel disease, irritable bowel syndrome, myocardial infarction, multiple sclerosis, severe obesity, osteoporosis, Parkinson’s disease, peptic ulcer disease, peripheral artery disease, psoriasis, rheumatoid arthritis, schizophrenia, and stroke or transient ischemic attack.

CV = cardiovascular; MI = myocardial infarction; RCS = restricted cubic splines.