Table 2.
BMI and WC Multivariable Associations With Cancer Incidence
| BMI (No. at Risk = 20,667) |
WC (No. at Risk = 14,623) |
|||||
|---|---|---|---|---|---|---|
| Events | HR (95% CI) | P Value | Events | HR (95% CI) | P Value | |
| Overall cancer | 2,619 | 1.03 (0.98-1.07) | 0.25 | 1,789 | 1.07 (1.01-1.13) | 0.020 |
| GI cancer | 534 | 1.14 (1.03-1.25) | 0.008 | 328 | 1.22 (1.07-1.40) | 0.003 |
| Colorectal cancer | 338 | 1.14 (1.01-1.28) | 0.040 | 206 | 1.21 (1.02-1.43) | 0.027 |
| Lung cancer | 295 | 0.77 (0.67-0.89) | <0.001 | 182 | 0.85 (0.70-1.02) | 0.084 |
| Melanoma | 165 | 1.05 (0.89-1.24) | 0.53 | 132 | 1.04 (0.85-1.29) | 0.68 |
| Hematologic cancer | 194 | 0.97 (0.83-1.14) | 0.75 | 142 | 0.92 (0.74-1.13) | 0.41 |
| Bladder cancer | 176 | 0.98 (0.82-1.18) | 0.84 | 129 | 1.07 (0.84-1.33) | 0.65 |
| Prostate cancer | 408 | 1.02 (0.89-1.16) | 0.80 | 283 | 1.13 (0.96-1.32) | 0.15 |
| Breast cancer | 455 | 1.04 (0.95-1.14) | 0.39 | 320 | 1.08 (0.95-1.22) | 0.23 |
| Gynecologic cancer | 128 | 1.34 (1.16-1.55) | <0.001 | 93 | 1.32 (1.07-1.63) | 0.010 |
BMI and WC are standardized. Multivariable model is adjusted for age, sex, diabetes mellitus, systolic blood pressure, hypertension treatment, smoking status, and cholesterol ratio. Effect sizes for BMI and WC were expressed per 1-SD change. P values <0.05 were considered to indicate statistical significance. SDs for BMI and WC are 4.8 kg/m2 and 14.3 cm, respectively.
BMI = body mass index; GI = gastrointestinal; WC = waist circumference.