Table 4.

Computed Tomographic Adipose Depot Multivariable Model Associations With Cancer Incidence

	Visceral Adipose Tissue		Pericardial Adipose Tissue		Intrathoracic Adipose Tissue		Subcutaneous Adipose Tissue		Liver Phantom Ratio
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Overall cancer (n/N = 394/3,077)	1.22 (1.05-1.43)	0.011	1.14 (1.02-1.27)	0.018	1.11 (0.97-1.27)	0.12	0.95 (0.79-1.14)	0.56	1.02 (0.92-1.14)	0.70
Gastrointestinal cancer (n/N = 49/3,077	1.11 (0.73-1.68)	0.62	1.08 (0.79-1.47)	0.62	1.33 (0.97-1.83)	0.078	1.47 (0.88-2.43)	0.14	1.07 (0.78-1.46)	0.67
Colorectal cancer (n/N = 28/3,077)	1.55 (0.90-2.67)	0.11	1.03 (0.67-1.57)	0.91	1.32 (0.85-2.05)	0.21	1.70 (0.89-3.24)	0.11	0.97 (0.66-1.43)	0.90
Lung cancer (n/N = 21/3,077)	1.92 (1.01-3.65)	0.045	1.51 (1.01-2.26)	0.044	1.51 (0.87-2.62)	0.15	1.53 (0.67-3.51)	0.31	0.85 (0.58-1.26)	0.43
Melanoma (n/N = 54/3,077)	1.56 (1.02-2.37)	0.038	1.40 (1.07-1.82)	0.013	1.38 (1.00-1.91)	0.047	1.09 (0.65-1.83)	0.75	0.92 (0.68-1.23)	0.56
Hematologic cancer (n/N = 43/3,077)	0.96 (0.60-1.54)	0.88	0.76 (0.51-1.12)	0.17	0.70 (0.44-1.11)	0.13	0.91 (0.50-1.64)	0.74	1.31 (0.89-1.93)	0.18
Bladder cancer (n/N = 30/3,077)	1.16 (0.71-1.91)	0.55	1.18 (0.84-1.67)	0.34	0.84 (0.52-1.34)	0.46	1.07 (0.50-2.28)	0.86	1.05 (0.71-1.54)	0.80
Prostate cancer (n/N = 81/1,595)	1.29 (0.95-1.76)	0.10	1.11 (0.89-1.39)	0.34	1.07 (0.82-1.40)	0.63	1.05 (0.67-1.63)	0.84	0.93 (0.75-1.17)	0.54
Breast cancer (n/N = 84/1,482)	1.29 (0.86-1.93)	0.22	1.22 (0.93-1.61)	0.15	1.03 (0.68-1.57)	0.88	0.94 (0.64-1.38)	0.77	0.92 (0.72-1.19)	0.53
Gynecologic cancer (n/N = 21/1,482)	1.03 (0.48-2.21)	0.94	0.61 (0.31-1.23)	0.17	1.46 (0.70-3.02)	0.31	0.39 (0.19-0.79)	0.009	1.15 (0.68-1.94)	0.60

Adiposity measures are standardized. Decreasing liver phantom ratio corresponds to a greater amount of liver fat. Multivariable model includes variables from main analyses (age, sex, diabetes mellitus, systolic blood pressure, hypertension treatment, smoking status, and cholesterol ratio) and body mass index. Displayed events (n/N) are those of visceral adipose tissue analyses. Event numerator and denominator vary slightly for other adipose depots analyses. Effect sizes were expressed per 1-SD change. Values of P < 0.05 were considered to indicate statistical significance. SDs for adiposity measures are 1,011.4 cm³ (visceral), 1,390.9 cm³ (subcutaneous), 42.9 cm³ (pericardial), 61.6 cm³ (intrathoracic), and 9.7 (liver phantom ratio).