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. 2021 Mar 31;2:41–51. doi: 10.1016/j.crimmu.2021.03.003

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Upregulated genes associated with inflammation and lupus, and downregulated genes associated with skin homeostasis in canine DLE skin. Boxplots of significantly upregulated genes in DLE versus healthy canine tissue previously associated with inflammation and lupus are presented as follows: (A) IFNG, (B) ISG15, (C) CXCL10, (D) FAS, (E) CCL4, (F) CCL5, (G) CCL19 and (H) CXCL13. Significantly downregulated genes associated with keratinocyte and skin homeostasis are presented as follows: (I) CCL24, (J) CCL27, (K) WIF1, (L) EDA, (M) FOXO1, (N) PPARG. (O) CYP1A1 trended lower and (P) CYP1B1 exhibited significantly lower expression in DLE lesional skin. (n=7 DLE and n=5 healthy controls, student’s t test and/or Mann Whitney U tests significant as indicated).