Fig. 3.
Immunohistochemical confirmation of protein-level expression of key immunopathogenesis genes in canine DLE. Immunohistochemistry staining of interferon gamma (IFNγ) and CXCL10 in canine DLE and healthy skin (10x). IFNγ exhibits punctate/cellular expression (black arrows), and is most prevalent around the dermoepidermal junction. CXCL10 is expressed throughout the tissue, and is most prominently expressed by keratinocytes in the epidermis (white arrows; scale bar = 300 μm).