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. 2021 Mar 31;2:41–51. doi: 10.1016/j.crimmu.2021.03.003

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Cell type analysis reveals influx of a number of both adaptive and innate immune cell subtypes in canine DLE lesions. (A) Total CD45 infiltrate as approximated by NanoString nSolver. (B) Z-scored cell type scores from NanoString Advanced Analysis. Heatmap generated with Morpheus software. Cell type scores by disease state for (C) T-cells (p-value = 6.72 × 10-7), (D) Th1 cells (p-value = 1.09 × 10-9), (E) cytotoxic cells (p-value = 6.21 × 10-7), (F) B-cells (p-value = 3.12 × 10-6), (G) NK CD56dim cells, (H) neutrophils (p-value = 6.51 × 10-4), (I) dendritic cells and (J) dermal CD103+ dendritic cells. (n = 6 DLE and n = 5 healthy controls, student’s t tests and/or Mann Whitney U tests significant as indicated).