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. 2021 Dec 29;8:350–360. doi: 10.1016/j.aninu.2021.11.005

Table 2.

Receptors for common SCFA and their related interaction.

Receptors Interaction References
GPR41/FFAR3 It has more affinity with propionate and least with acetate. Koh et al. (2016)
GPR43/FFAR2 It has more affinity with propionate and acetate and least affinity with butyrate. Mandaliya and Seshadri (2019)
GPR109A/HCAR2 Butyrate has attraction with GPR109A or HCAR2. Dalile et al. (2019)

SCFA = short chain fatty acids; GPR = G protein-coupled receptor; FFAR = free fatty acid receptor; HCAR2 = hydroxycarboxylic acid receptor 2.