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Canonical pathways induced by adrenergic receptor signalling. The higher ligand concentration leads to phosphorylation of adrenergic receptors by GRK2. Phosphorylated adrenergic receptors bind to β-arrestin 1. This drives the receptor internalization and which either may get dephosphorylated and recycled back the adrenergic receptor at the plasma membrane or degraded in the lysosome.
