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Representative hematoxylin-eosin-stained sections of 4T1 tumors injected with SPIO@AuNS, with (B, D) or without (A, C) NIR surface laser treatment (4 W/cm2 for 3 min). The percentage of tumor necrosis in laser-treated mice was significantly higher than that in mice that did not receive laser treatment (91% vs. 3.2%, p <0.0001).
