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. 2022 Apr 26;22:453. doi: 10.1186/s12885-022-09566-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — LINC00022 promoted the development of CRC in vivo. HCT116 cells with stable low expression of LINC00022 or CaCo-2 cells with stable overexpression of LINC00022 were injected subcutaneously into nude mice. (a) Representative images of tumor tissues in nude mice. (b) The volumes were calculated after being injected with LINC00022-silenced cells or -overexpressed cells. (c and d) The mRNA levels of LINC00022, miR-375-3p, and FOXF1 were detected in tumor tissues. (e) Relative protein levels of c-Myc, pro caspase 3, cleaved caspase 3, MMP2, and VEGFA in tumor tissues. (f) Immunohistochemical staining of FOXF1 in tumor tissues. Scale bar = 50 μm. β-actin served as the internal control. Data were presented as mean ± standard deviation (SD). N = 6. *P < 0.05, **P < 0.01, and ***P < 0.001 vs Lv-anti-NC group or Lv-NC group. FOXF1, Forkhead Box F1; MMP2, matrix metalloproteinase 2; VEGFA, vascular endothelial growth factor-A