Table 2.

Results of significant association of genetic variants with metabolic syndrome and its components (waist circumference and systolic blood pressure) in Korean adults^a

No.	SNP	Chr	Minor allele	MAF		Gene	Function	MetS (controls 5591; cases 2785)		Waist circumference		SBP
				Cases	Controls			OR (95% CI)	Add p value	Beta ± SE	Add p value	Beta ± SE	Add p value
1	rs651821	11	C	0.350	0.278	APOA5	Intron	1.45 (1.32–1.58)	2.08 × 10−15	0.22 ± 0.17	0.201	0.53 ± 0.35	0.129
2	rs662799	11	G	0.349	0.278	APOA5	Intron	1.45 (1.32–1.58)	2.35 × 10−15	0.22 ± 0.17	0.211	0.53 ± 0.35	0.126
3	rs2075291	11	A	0.107	0.069	APOA5	Intron	1.70 (1.47–1.97)	1.42 × 10−12	0.43 ± 0.29	0.141	0.41 ± 0.58	0.480
4	rs75198898	11	A	0.107	0.069	ZPR1	Intron	1.69 (1.46–1.96)	2.25 × 10−12	0.38 ± 0.29	0.186	0.48 ± 0.58	0.404
5	rs113932726	11	T	0.107	0.069	ZPR1	Intron	1.69 (1.46–1.96)	2.25 × 10−12	0.38 ± 0.29	0.186	0.48 ± 0.58	0.404
6	rs3741297	11	T	0.107	0.070	ZPR1	Intron	1.69 (1.46–1.95)	2.97 × 10−12	0.41 ± 0.29	0.155	0.39 ± 0.58	0.498
7	rs74368849	11	A	0.107	0.071	BUD13	Intron	1.65 (1.42–1.90)	2.54 × 10−11	0.35 ± 0.29	0.221	0.39 ± 0.58	0.500
8	rs167012	5	C	0.421	0.366	FBXL17	Intron	1.29 (1.18–1.40)	1.52 × 10−8	0.31 ± 0.17	0.066	0.77 ± 0.33	0.020

Abbreviations: SNP Single nucleotide polymorphism, Chr Chromosome, MAF Minor allele frequency, MetS Metabolic syndrome, OR Odds ratio, CI Confidence interval, SE Standard error, SBP Systolic blood pressure, DBP Diastolic blood pressure, FBG Fasting blood glucose, HDL High-density lipoprotein, Add Additive model

^aModels were adjusted for age, residential area, and sex