Table 3.
Results of significant association of genetic variants with components of the metabolic syndrome (diastolic blood pressure, fasting blood glucose, HDL cholesterol, and triglyceride) in Korean adultsa
| No. | SNP | Chr | Minor allele | Gene | DBP | FBG | HDL cholesterol | Triglyceride | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta ± SE | Add p value | Beta ± SE | Add p value | Beta ± SE | Add p value | Beta ± SE | Add p value | |||||
| 1 | rs651821 | 11 | C | APOA5 | 0.11 ± 0.23 | 0.617 | 0.55 ± 0.43 | 0.195 | − 2.02 ± 0.20 | 1.08 × 10−22 | 33.44 ± 2.14 | 8.45 × 10−54 |
| 2 | rs662799 | 11 | G | APOA5 | 0.12 ± 0.23 | 0.612 | 0.54 ± 0.43 | 0.203 | − 2.02 ± 0.20 | 8.70 × 10−23 | 33.44 ± 2.14 | 8.26 × 10−54 |
| 3 | rs2075291 | 11 | A | APOA5 | 0.31 ± 0.38 | 0.406 | 1.46 ± 0.71 | 0.040 | − 3.37 ± 0.34 | 7.41 × 10−23 | 50.36 ± 3.58 | 2.81 × 10−44 |
| 4 | rs75198898 | 11 | A | ZPR1 | 0.37 ± 0.38 | 0.327 | 1.43 ± 0.71 | 0.044 | − 3.34 ± 0.34 | 1.59 × 10−22 | 49.93 ± 3.57 | 1.23 × 10−43 |
| 5 | rs113932726 | 11 | T | ZPR1 | 0.37 ± 0.38 | 0.327 | 1.43 ± 0.71 | 0.044 | − 3.34 ± 0.34 | 1.59 × 10−22 | 49.93 ± 3.57 | 1.23 × 10−43 |
| 6 | rs3741297 | 11 | T | ZPR1 | 0.27 ± 0.38 | 0.475 | 1.44 ± 0.71 | 0.042 | − 3.36 ± 0.34 | 7.42 × 10−23 | 49.95 ± 3.57 | 1.03 × 10−43 |
| 7 | rs74368849 | 11 | A | BUD13 | 0.39 ± 0.38 | 0.303 | 1.41 ± 0.70 | 0.046 | − 3.14 ± 0.34 | 2.79 × 10−20 | 47.40 ± 3.56 | 9.33 × 10−40 |
| 8 | rs167012 | 5 | C | FBXL17 | 0.44 ± 0.22 | 0.041 | 1.33 ± 0.41 | 0.001 | − 0.44 ± 0.20 | 0.025 | 8.94 ± 2.08 | 1.79 × 10−5 |
Abbreviations: SNP Single nucleotide polymorphism, Chr Chromosome, MAF Minor allele frequency, MetS Metabolic syndrome, OR Odds ratio, CI Confidence interval, SE Standard error, SBP Systolic blood pressure, DBP Diastolic blood pressure, FBG Fasting blood glucose, HDL High-density lipoprotein, Add Additive model
aModels were adjusted for age, residential area, and sex