Comparison 1. evening versus morning dosing regimen.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 24 h mean systolic blood pressure	21	2152	Mean Difference (Random, 95% CI)	‐1.71 [‐2.78, ‐0.65]
1.1 β‐blockers	1	82	Mean Difference (Random, 95% CI)	1.4 [‐3.60, 6.40]
1.2 α‐blockers	1	39	Mean Difference (Random, 95% CI)	‐5.1 [‐8.43, ‐1.77]
1.3 ACEIs	5	277	Mean Difference (Random, 95% CI)	‐0.93 [‐3.11, 1.24]
1.4 ARBs	6	632	Mean Difference (Random, 95% CI)	‐0.87 [‐2.12, 0.38]
1.5 CCBs	7	951	Mean Difference (Random, 95% CI)	‐1.64 [‐3.39, 0.12]
1.6 Diuretics	2	171	Mean Difference (Random, 95% CI)	‐6.22 [‐9.34, ‐3.10]
2 24 h mean diastolic blood pressure	21	2158	Std. Mean Difference (Random, 95% CI)	‐1.38 [‐2.13, ‐0.62]
2.1 β‐blockers	1	88	Std. Mean Difference (Random, 95% CI)	1.1 [‐2.27, 4.47]
2.2 α‐blockers	1	39	Std. Mean Difference (Random, 95% CI)	‐2.7 [‐5.17, ‐0.23]
2.3 ACEIs	5	277	Std. Mean Difference (Random, 95% CI)	‐1.56 [‐3.18, 0.06]
2.4 ARBs	6	632	Std. Mean Difference (Random, 95% CI)	‐0.72 [‐1.86, 0.43]
2.5 CCBs	7	951	Std. Mean Difference (Random, 95% CI)	‐0.61 [‐1.58, 0.35]
2.6 Diuretics	2	171	Std. Mean Difference (Random, 95% CI)	‐5.60 [‐6.82, ‐4.38]
3 morning mean systolic blood pressure	3	391	Mean Difference (Random, 95% CI)	‐1.62 [‐4.19, 0.95]
3.1 β‐blockers	1	82	Mean Difference (Random, 95% CI)	1.5 [‐2.15, 5.15]
3.2 CCBs	2	309	Mean Difference (Random, 95% CI)	‐2.68 [‐4.46, ‐0.89]
4 morning mean diastolic blood pressure	3	391	Mean Difference (Random, 95% CI)	‐1.21 [‐3.28, 0.86]
4.1 β‐blockers	1	82	Mean Difference (Random, 95% CI)	0.4 [‐2.09, 2.89]
4.2 CCBs	2	309	Mean Difference (Random, 95% CI)	‐1.87 [‐4.32, 0.58]
5 overall adverse events	5	702	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.37, 1.65]
5.1 ACEIs	1	120	Risk Ratio (M‐H, Random, 95% CI)	0.5 [0.10, 2.63]
5.2 CCBs	2	403	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.11, 2.49]
5.3 Diuretics	2	179	Risk Ratio (M‐H, Random, 95% CI)	1.66 [0.56, 4.90]
6 withdrawals due to adverse events	6	1042	Risk Ratio (M‐H, Random, 95% CI)	0.53 [0.26, 1.07]
6.1 ACEIs	1	120	Risk Ratio (M‐H, Random, 95% CI)	1.0 [0.06, 15.62]
6.2 ARBs	2	375	Risk Ratio (M‐H, Random, 95% CI)	0.30 [0.06, 1.41]
6.3 CCBs	3	547	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.26, 1.33]