Fig. 2.

Possible correlation between lung-transplant, Sars-Cov 2 infection, HLH and cholangitis. Description: Sars-CoV 2 infections led the patient to bi-lung transplant. However, Sars-CoV 2 can be the trigger of both HLH and cholangitis. Also HLH may be associated with cholangitis. Furthermore, HLH treatments contribuited to impair the patient immunity and they increased the already higher risk of infection of lung transplant recipients. So, bacterial and viral infections have acted as a trigger for HLH, thus causing a vicious circle.