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. 2022 Apr 26;28(7):366.e1–366.e7. doi: 10.1016/j.jtct.2022.04.017

Figure 4.

Figure 4

T-cell response to SARS-CoV-2 mRNA vaccination. SARS-CoV-2-specific T-cell responses of helper (A) and cytotoxic cells (C) is shown for CAR-T patients and healthy controls (B, D). Patients after CAR-T cell therapy showed a significant increase in specific T-helper cells after the 2nd vaccination (A). Compared with healthy controls (E), significantly higher levels of SARS-CoV-2 specific CD4+ T-cells were obtained for IL-2, TNFα, CD40L, and IL-2+CD40L. Similar outcomes, albeit less pronounced than for helper T-cells, were observed for cytotoxic T-cells (C). Antigen-specific cytotoxic T-cells from healthy vaccine recipients and CAR-T19 patients were similar in frequency (D).