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. 2022 Apr 25;146:105443. doi: 10.1016/j.compbiomed.2022.105443

Table 4.

Top 20 KEGG pathways ordered by combined score for A549 cells (paired healthy versus SARS-CoV-2 setting). See KEGG IDs for links to the pathway maps description.

KEGG Pathway p-value c-score
Measles (map05162) 1.02E-08 295.14
Influenza A (map05164) 1.02E-08 252.18
Herpes simplex virus 1 infection (map05168) 7.16E-10 177.20
Epstein-Barr virus infection (map05169) 4.82E-07 156.14
TNF signaling pathway (map04668) 1.11E-07 153.86
Coronavirus disease (map05171) 3.78E-07 150.32
RIG-I-like receptor signaling pathway (map04622) 3.68E-04 120.34
NOD-like receptor signaling pathway (map04621) 9.37E-06 119.63
Legionellosis (map05134) 1.77E-05 118.99
Hepatitis C (map05160) 1.79E-05 118.31
TNF signaling pathway (map04668) 8.61E-05 116.25
Primary immunodeficiency (map05340) 2.17E-03 116.00
Allograft rejection (map05330) 2.17E-03 116.00
Amoebiasis (map05146) 2.13E-06 111.38
African trypanosomiasis (map05143) 1.50E-04 111.14
Rheumatoid arthritis (map05323) 3.12E-06 110.93
Legionellosis (map05134) 1.12E-03 105.75
Antigen processing and presentation (map04612) 5.58E-04 100.66
JAK-STAT signaling pathway (map04630) 1.07E-06 96.92
NF-kappa B signaling pathway (map04064) 3.68E-04 92.76