Table 4.
Top 20 KEGG pathways ordered by combined score for A549 cells (paired healthy versus SARS-CoV-2 setting). See KEGG IDs for links to the pathway maps description.
| KEGG Pathway | p-value | c-score |
|---|---|---|
| Measles (map05162) | 1.02E-08 | 295.14 |
| Influenza A (map05164) | 1.02E-08 | 252.18 |
| Herpes simplex virus 1 infection (map05168) | 7.16E-10 | 177.20 |
| Epstein-Barr virus infection (map05169) | 4.82E-07 | 156.14 |
| TNF signaling pathway (map04668) | 1.11E-07 | 153.86 |
| Coronavirus disease (map05171) | 3.78E-07 | 150.32 |
| RIG-I-like receptor signaling pathway (map04622) | 3.68E-04 | 120.34 |
| NOD-like receptor signaling pathway (map04621) | 9.37E-06 | 119.63 |
| Legionellosis (map05134) | 1.77E-05 | 118.99 |
| Hepatitis C (map05160) | 1.79E-05 | 118.31 |
| TNF signaling pathway (map04668) | 8.61E-05 | 116.25 |
| Primary immunodeficiency (map05340) | 2.17E-03 | 116.00 |
| Allograft rejection (map05330) | 2.17E-03 | 116.00 |
| Amoebiasis (map05146) | 2.13E-06 | 111.38 |
| African trypanosomiasis (map05143) | 1.50E-04 | 111.14 |
| Rheumatoid arthritis (map05323) | 3.12E-06 | 110.93 |
| Legionellosis (map05134) | 1.12E-03 | 105.75 |
| Antigen processing and presentation (map04612) | 5.58E-04 | 100.66 |
| JAK-STAT signaling pathway (map04630) | 1.07E-06 | 96.92 |
| NF-kappa B signaling pathway (map04064) | 3.68E-04 | 92.76 |