Table 8.
GO biological processes with highest joint ranks for SARS-CoV-2 conditions. Counts correspond to the normalized number of occurrences of each process within each condition.
| GO Biological Processes | A549 SARS-CoV-2 |
NHBE SARS-CoV-2 |
Calu3 SARS-CoV-2 |
Biopsy SARS-CoV-2 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| count | p-value | c-score | count | p-value | c-score | count | p-value | c-score | count | p-value | c-score | |
| cytokine-mediated signaling pathway (GO:0019221) | 1.00 | 6.95E-3 | 6.06E+5 | 0.75 | 2.79E-4 | 6.06E+5 | 1.00 | 2.29E-3 | 1.02E+3 | 0.60 | 2.79E-4 | 6.06E+5 |
| cellular response to interferon-gamma (GO:0071346) | 0.66 | 1.15E-7 | 5.61E+2 | 0.88 | 4.31E-3 | 3.97E+2 | 0.83 | 2.36E-4 | 1.13E+3 | 0.56 | 1.37E-18 | 1.56E+3 |
| cellular response to cytokine stimulus (GO:0071345) | 0.61 | 2.50E-4 | 6.55E+5 | 0.92 | 2.50E-4 | 6.55E+5 | 0.67 | 4.14E-4 | 3.67E+2 | 0.44 | 2.50E-4 | 6.55E+5 |
| inflammatory response (GO:0006954) | 0.45 | 5.30E-5 | 6.46E+2 | 0.75 | 3.90E-4 | 1.47E+2 | 0.50 | 3.23E-5 | 2.30E+2 | 0.72 | 3.23E-23 | 3.84E+2 |
| protein modification by small protein removal (GO:0070646) | 0.49 | 7.88E-3 | 1.74E+2 | 0.46 | 7.88E-3 | 1.68E+2 | 0.67 | 6.62E-3 | 1.39E+2 | 0.63 | 2.74E-4 | 1.25E+2 |
| regulation of immune response (GO:0050776) | 0.34 | 3.64E-7 | 7.11E+2 | 0.71 | 5.14E-3 | 1.85E+2 | 0.69 | 3.32E-3 | 2.62E+2 | 0.72 | 2.84E-25 | 5.29E+2 |
| mRNA splicing, via spliceosome (GO:0000398) | 0.51 | 2.08E-6 | 7.38E+2 | 0.62 | 1.69E-4 | 6.89E+2 | 0.42 | 3.83E-5 | 3.18E+2 | 0.65 | 1.11E-5 | 5.68E+2 |
| mRNA processing (GO:0006397) | 0.51 | 2.88E-6 | 7.02E+2 | 0.62 | 3.98E-4 | 6.99E+2 | 0.42 | 3.83E-5 | 3.67E+2 | 0.65 | 1.27E-5 | 6.39E+2 |
| DNA metabolic process (GO:0006259) | 0.45 | 5.44E-4 | 2.63E+2 | 0.38 | 7.56E-4 | 4.22E+1 | 0.22 | 7.56E-4 | 1.40E+2 | 1.00 | 2.59E-6 | 1.97E+2 |
| interferon-gamma-mediated signaling pathway (GO:0060333) | 0.54 | 1.03E-3 | 6.97E+2 | 0.38 | 9.63E-4 | 6.97E+2 | 0.75 | 1.14E-6 | 1.49E+3 | 0.21 | 5.67E-8 | 1.28E+3 |
| epidermis development (GO:0008544) | 0.54 | 1.83E-4 | 1.44E+3 | 0.88 | 2.21E-22 | 2.15E+3 | 0.08 | 8.41E-6 | 5.33E+2 | 0.35 | 6.74E-4 | 6.99E+2 |
| RNA splicing, with bulged adenosine as nucleophile (GO:0000377) | 0.48 | 3.31E-6 | 7.02E+2 | 0.62 | 4.30E-4 | 6.75E+2 | 0.42 | 3.83E-5 | 3.36E+2 | 0.56 | 1.27E-5 | 5.35E+2 |
| positive regulation of response to external stimulus (GO:0032103) | 0.39 | 3.65E-3 | 5.26E+2 | 0.67 | 1.82E-3 | 1.36E+2 | 0.69 | 8.96E-3 | 3.29E+2 | 0.35 | 2.81E-10 | 3.26E+2 |
| chemokine-mediated signaling pathway (GO:0070098) | 0.39 | 6.02E-5 | 3.99E+3 | 0.67 | 1.55E-4 | 5.04E+2 | 0.67 | 1.16E-3 | 4.40E+2 | 0.37 | 1.19E-8 | 4.94E+2 |
| DNA repair (GO:0006281) | 0.45 | 4.48E-3 | 3.13E+2 | 0.25 | 4.65E-3 | 3.81E+1 | 0.22 | 4.65E-3 | 1.36E+2 | 0.95 | 9.43E-3 | 1.36E+2 |
| extracellular matrix organization (GO:0030198) | 0.32 | 1.13E-3 | 1.05E+2 | 1.00 | 3.31E-8 | 1.70E+2 | 0.28 | 1.81E-3 | 6.33E+1 | 0.44 | 2.96E-6 | 9.18E+1 |
| neutrophil mediated immunity (GO:0002446) | 0.53 | 3.68E-3 | 2.39E+2 | 0.38 | 2.14E-24 | 1.93E+2 | 0.67 | 2.16E-5 | 2.48E+2 | 0.28 | 1.57E-8 | 1.12E+2 |
| cellular response to DNA damage stimulus (GO:0006974) | 0.47 | 2.65E-3 | 1.29E+2 | 0.29 | 4.65E-3 | 1.10E+2 | 0.11 | 2.73E-17 | 1.42E+2 | 0.95 | 6.21E-5 | 1.42E+2 |
| neutrophil activation involved in immune response (GO:0002283) | 0.49 | 6.01E-21 | 2.39E+2 | 0.50 | 9.44E-3 | 1.93E+2 | 0.67 | 2.16E-5 | 2.47E+2 | 0.28 | 4.96E-9 | 8.95E+1 |
| neutrophil degranulation (GO:0043312) | 0.49 | 2.12E-21 | 2.46E+2 | 0.50 | 8.99E-3 | 2.00E+2 | 0.67 | 2.16E-5 | 2.55E+2 | 0.26 | 5.39E-8 | 9.08E+1 |
| cellular response to chemokine (GO:1990869) | 0.36 | 8.06E-5 | 3.65E+3 | 0.62 | 1.94E-4 | 4.57E+2 | 0.72 | 1.75E-3 | 3.99E+2 | 0.26 | 4.05E-8 | 4.45E+2 |
| protein ubiquitination (GO:0016567) | 0.45 | 9.45E-3 | 1.70E+2 | 0.29 | 9.45E-3 | 1.70E+2 | 0.19 | 9.45E-3 | 8.06E+1 | 0.81 | 9.45E-3 | 1.55E+2 |
| cellular protein modification process (GO:0006464) | 0.49 | 1.52E-19 | 1.39E+2 | 0.29 | 1.93E-3 | 1.20E+2 | 0.25 | 1.93E-3 | 8.82E+1 | 0.70 | 2.97E-6 | 1.19E+2 |
| antigen receptor-mediated signaling pathway (GO:0050851) | 0.49 | 6.48E-6 | 8.87E+1 | 0.67 | 3.95E-3 | 8.87E+1 | 0.14 | 3.73E-6 | 1.63E+2 | 0.26 | 4.15E-11 | 1.63E+2 |
| defense response to symbiont (GO:0140546) | 0.39 | 7.76E-6 | 9.11E+5 | 0.38 | 7.76E-6 | 9.11E+5 | 0.75 | 1.15E-10 | 1.66E+3 | 0.23 | 7.76E-6 | 9.11E+5 |