Table 9.
GO biological processes with highest joint ranks for all viruses for the A549 cell type. Counts correspond to the normalized number of occurrences of each process within each condition.
| GO Biological Processes | A549 SARS-CoV-2 |
A549 RSV |
A549 HPIV3 |
A549 IAV |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| count | p-value | c-score | count | p-value | c-score | count | p-value | c-score | count | p-value | c-score | |
| epidermis development (GO:0008544) | 0.54 | 1.83E-4 | 1.44E+3 | 1.00 | 4.96E-6 | 7.01E+2 | 1.00 | 1.83E-4 | 1.44E+3 | 1.00 | 2.38E-14 | 9.94E+2 |
| cellular response to interferon-gamma (GO:0071346) | 0.66 | 1.15E-7 | 5.61E+2 | 0.85 | 1.15E-7 | 2.91E+2 | 0.92 | 1.15E-7 | 7.32E+2 | 0.86 | 4.74E-6 | 2.91E+2 |
| cytokine-mediated signaling pathway (GO:0019221) | 1.00 | 6.95E-3 | 6.06E+5 | 0.74 | 6.95E-3 | 9.57E+1 | 0.90 | 6.95E-3 | 4.40E+2 | 1.00 | 2.87E-10 | 4.36E+2 |
| inflammatory response (GO:0006954) | 0.45 | 5.30E-5 | 6.46E+2 | 0.97 | 1.23E-7 | 2.33E+2 | 0.92 | 5.30E-5 | 1.97E+2 | 1.00 | 3.90E-4 | 2.53E+2 |
| interferon-gamma-mediated signaling pathway (GO:0060333) | 0.54 | 1.03E-3 | 6.97E+2 | 0.74 | 1.03E-3 | 2.19E+2 | 0.92 | 1.03E-3 | 9.72E+2 | 0.61 | 8.73E-3 | 2.19E+2 |
| antigen receptor-mediated signaling pathway (GO:0050851) | 0.49 | 6.48E-6 | 8.87E+1 | 0.68 | 2.38E-4 | 8.87E+1 | 0.63 | 6.48E-6 | 8.87E+1 | 0.59 | 1.92E-3 | 8.87E+1 |
| complement activation, classical pathway (GO:0006958) | 0.39 | 6.59E-3 | 8.66E+3 | 0.91 | 4.52E-5 | 8.66E+3 | 0.86 | 6.59E-3 | 8.66E+3 | 0.78 | 4.54E-5 | 8.66E+3 |
| skin development (GO:0043588) | 0.46 | 9.85E-4 | 3.80E+2 | 0.71 | 8.82E-6 | 3.80E+2 | 0.59 | 4.62E-4 | 3.80E+2 | 0.57 | 9.85E-4 | 3.80E+2 |
| cellular response to cytokine stimulus (GO:0071345) | 0.61 | 2.50E-4 | 6.55E+5 | 0.41 | 5.74E-5 | 8.36E+1 | 0.55 | 5.74E-5 | 1.49E+2 | 0.71 | 5.74E-5 | 1.69E+2 |
| chemokine-mediated signaling pathway (GO:0070098) | 0.39 | 6.02E-5 | 3.99E+3 | 0.76 | 6.02E-5 | 5.04E+2 | 0.71 | 6.02E-5 | 8.65E+2 | 0.67 | 7.71E-3 | 5.04E+2 |
| humoral immune response via immunoglobulin (GO:0002455) | 0.37 | 8.06E-5 | 5.89E+3 | 0.91 | 8.06E-5 | 5.89E+3 | 0.82 | 8.06E-5 | 5.89E+3 | 0.76 | 5.90E-5 | 5.89E+3 |
| positive regulation of external stimulus response (GO:0032103) | 0.39 | 3.65E-3 | 5.26E+2 | 0.56 | 3.65E-3 | 1.43E+2 | 0.71 | 3.65E-3 | 1.95E+2 | 0.76 | 4.51E-3 | 1.47E+2 |
| epidermal cell differentiation (GO:0009913) | 0.36 | 9.67E-4 | 9.29E+2 | 0.88 | 1.21E-7 | 9.29E+2 | 0.71 | 8.76E-5 | 9.29E+2 | 0.76 | 9.67E-4 | 9.29E+2 |
| keratinocyte differentiation (GO:0030216) | 0.36 | 1.51E-3 | 1.29E+3 | 0.85 | 1.31E-6 | 1.29E+3 | 0.71 | 6.21E-4 | 1.29E+3 | 0.76 | 1.51E-3 | 1.29E+3 |
| regulation of immune response (GO:0050776) | 0.34 | 3.64E-7 | 7.11E+2 | 0.94 | 3.06E-9 | 7.11E+2 | 0.88 | 3.64E-7 | 2.29E+2 | 0.88 | 1.18E-8 | 7.11E+2 |
| cellular response to chemokine (GO:1990869) | 0.36 | 8.06E-5 | 3.65E+3 | 0.68 | 8.06E-5 | 4.57E+2 | 0.67 | 8.06E-5 | 7.92E+2 | 0.59 | 1.94E-4 | 4.57E+2 |
| positive regulation of defense response (GO:0031349) | 0.36 | 2.07E-3 | 8.24E+2 | 0.38 | 2.07E-3 | 1.36E+2 | 0.45 | 2.07E-3 | 2.17E+2 | 0.75 | 2.07E-3 | 1.37E+2 |
| exogenous peptide antigen via MHC class II (GO:0019886) | 0.48 | 6.36E-3 | 6.51E+2 | 0.41 | 6.36E-3 | 6.51E+2 | 0.43 | 6.36E-3 | 6.51E+2 | 0.29 | 9.02E-3 | 6.51E+2 |
| peptide antigen via MHC class II (GO:0002495) | 0.48 | 6.81E-3 | 6.34E+2 | 0.38 | 6.81E-3 | 6.34E+2 | 0.43 | 6.81E-3 | 6.34E+2 | 0.27 | 9.02E-3 | 6.34E+2 |
| positive regulation of chemotaxis (GO:0050921) | 0.31 | 6.20E-4 | 3.42E+2 | 0.88 | 3.37E-3 | 3.42E+2 | 0.80 | 6.20E-4 | 4.14E+2 | 0.82 | 6.71E-3 | 3.42E+2 |
| extracellular matrix organization (GO:0030198) | 0.32 | 1.13E-3 | 1.05E+2 | 0.53 | 1.13E-3 | 3.98E+1 | 0.59 | 1.13E-3 | 3.90E+1 | 0.57 | 1.13E-3 | 4.23E+1 |
| T cell receptor signaling pathway (GO:0050852) | 0.41 | 2.70E-3 | 1.16E+2 | 0.29 | 8.46E-4 | 5.79E+1 | 0.35 | 2.70E-3 | 6.64E+1 | 0.24 | 2.46E-3 | 3.68E+1 |
| presentation of exogenous peptide antigen (GO:0002478) | 0.45 | 7.80E-3 | 6.10E+2 | 0.26 | 7.80E-3 | 6.10E+2 | 0.31 | 7.80E-3 | 6.10E+2 | 0.16 | 9.02E-3 | 6.10E+2 |
| positive regulation of protein phosphorylation (GO:0001934) | 0.33 | 4.81E-3 | 5.19E+1 | 0.32 | 4.81E-3 | 5.19E+1 | 0.29 | 4.81E-3 | 5.19E+1 | 0.31 | 5.56E-3 | 5.19E+1 |
| mRNA processing (GO:0006397) | 0.51 | 2.88E-6 | 7.02E+2 | 0.18 | 2.34E-8 | 3.67E+2 | 0.29 | 3.83E-5 | 5.11E+2 | 0.20 | 2.88E-6 | 3.67E+2 |