Table 15Top GO biological processes ordered by combined score, for Calu3 cells.

GO Biological Process	p-value	c-score	Cluster
secondary alcohol biosynthetic process (GO:1902653)	7.95E-16	1990.21	0
regulation of ribonuclease activity (GO:0060700)	7.19E-05	1921.48	2
negative regulation of viral process (GO:0048525)	2.57E-26	1907.45	2
negative regulation of viral genome replication (GO:0045071)	8.48E-23	1896.45	2
cholesterol biosynthetic process (GO:0006695)	7.95E-16	1858.91	0
sterol biosynthetic process (GO:0016126)	2.75E-15	1541.71	0
defense response to symbiont (GO:0140546)	9.30E-31	1498.91	2
type I interferon signaling pathway (GO:0060337)	7.48E-22	1405.26	2
cellular response to type I interferon (GO:0071357)	7.48E-22	1405.26	2
defense response to virus (GO:0051607)	9.30E-31	1396.78	2
regulation of viral genome replication (GO:0045069)	9.17E-19	1016.38	2
regulation of nuclease activity (GO:0032069)	1.78E-04	880.78	2
positive regulation of extrinsic apoptotic signaling pathway (GO:1902043)	1.78E-04	880.78	2
cytokine-mediated signaling pathway (GO:0019221)	9.36E-44	869.33	2
isopentenyl diphosphate biosynthetic process (GO:0009240)	6.97E-03	735.60	0
negative regulation of lymphocyte differentiation (GO:0045620)	3.64E-04	546.31	2
positive regulation of gliogenesis (GO:0014015)	3.64E-04	546.31	2
positive regulation of smooth muscle cell differentiation (GO:1905065)	3.64E-04	546.31	2
negative regulation of innate immune response (GO:0045824)	9.07E-10	500.91	2
cellular response to interferon-gamma (GO:0071346)	2.10E-16	485.61	2
cellular response to cytokine stimulus (GO:0071345)	3.66E-28	483.06	2
positive regulation of heat generation (GO:0031652)	2.52E-03	479.71	2
exocyst localization (GO:0051601)	2.52E-03	479.71	2
regulation of fever generation (GO:0031620)	2.52E-03	479.71	2
positive regulation of glial cell proliferation (GO:0060252)	2.52E-03	479.71	2