TABLE 2.

EasyCIE-SSI Performance in the Training, Internal and External Validation Cohorts

	Training	Internal Validation	External Validation	p-Value*
Sensitivity
Superficial SSI	0.90 (0.82–0.95)	0.92 (0.79–1.00)	0.71 (0.66–0.75)	0.047
Deep SSI	1.00 (1.00–1.00)	1.00 (1.00–1.00)	0.81 (0.72–0.88)	0.757
Organ/Space SSI	0.92 (0.88–0.96)	0.96 (0.89–1.00)	0.90 (0.86–0.94)	0.334
SSI PATOS	1.00 (1.00–1.00)	0.95 (0.84–1.00)	0.88 (0.79–0.95)	0.665
Any SSI	0.91 (0.88–0.95)	0.94 (0.89–0.99)	0.79 (0.75–0.82)	0.002
Specificity
Superficial SSI	0.86 (0.85–0.87)	0.86 (0.84–0.87)	0.90 (0.90–0.91)	0.004
Deep SSI	0.85 (0.84–0.86)	0.85 (0.83–0.87)	0.89 (0.89–0.90)	0.127
Organ/Space SSI	0.87 (0.86–0.88)	0.87 (0.85–0.88)	0.90 (0.90–0.90)	0.443
SSI PATOS	0.85 (0.84–0.86)	0.86 (0.84–0.87)	0.89 (0.88–0.89)	0.156
Any SSI	0.89 (0.88–0.90)	0.88 (0.86–0.89)	0.92 (0.92–0.92)	0.012
AUC
Superficial SSI	0.879 (0.848–00.91)	0.887 (0.830–0.944)	0.805 (0.782–0.827)	0.008
Deep SSI	0.924 (0.919–00.93)	0.925 (0.917–0.933)	0.850 (0.810–0.890)	<0.0001
Organ/Space SSI	0.897 (0.876–00.92)	0.913 (0.883–0.943)	0.900 (0.882–0.919)	0.484
SSI PATOS	0.926 (0.921–00.93)	0.902 (0.849–0.954)	0.884 (0.845–0.924)	0.608
Any SSI	0.902 (0.884–00.92)	0.912 (0.884–0.940)	0.852 (0.837–0.868)	<0.0001

^*p-Value: comparison of EasyCIE-SSI performance on external validation cohort compared to internal validation cohort; SSI: Surgical Site Infection, PATOS: Present at the Time of Surgery, AUC: Area Under the Receiver Operating Curve