Figure 3.

The major cell types in the liver. It includes the parenchymal hepatocytes, which occupy about 60–80% of the total number of liver cells, and the non-parenchymal cells occupying approximately 20–40% of the total number. In the non-parenchymal cell, it consists of the liver sinusoidal endothelial cells (approximately 50% of the total number of non-parenchymal cells), phagocytic Kupffer cells (approximately 20%), lymphocytes (approximately 25%), biliary cells (approximately 5%), and hepatic stellate cells (approximately 1–8%). In the lymphocytes, it includes the T lymphocytes (approximately 63%), natural killer (NK) cells (approximately 31%), B lymphocytes (approximately 6%), and less than 1% of dendritic cells (DCs). In the T lymphocytes, it contains the conventional T cells, including CD4⁺ T cells and CD8⁺ T cells, and the unconventional T cells, including natural killer T (NKT) cells, TCRγδ T cells, and others.